Cyanoacrylate Inhibitors of the Hill Reaction III. Stereochemical and Electronic Aspects of Inhibitor Binding
نویسندگان
چکیده
Ethoxyethyl 3-octylamino-2-cyanoacrylate and related com pounds in which the amino group was replaced by N -C H 3, S, O and CH 2 were synthesized and their activity as inhibitors o f the Hill reaction in isolated pea chloroplasts determined. All com pounds showed moderate to high activity but there was no obvious correlation between activity and the electronic character o f the ester carbonyl group. The stereochemistry o f the various inhibitor m olecules was deduced from the PMR spectra and the possible influence o f stereochemistry on Hill inhibitory activity discussed. Replacement o f the olefinic proton in the 2-cyanoacrylates with a /?-alkyl substituent was examined and a specific relationship between the length o f the alkyl chain and activity was observed.
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